β-hemolytic streptococcal infections Continue treatment for at least 10 days.
Toxoplasmic encephalitis in patients w/ AIDS 600-1,200 mg IV/PO every 6 hr for 2 wk followed by 300-600 mg PO every 6 hr + pyrimethamine 25-75 mg PO daily for 8-10 wk. Give folinic acid 10-20 mg daily for higher doses of pyrimethamine. Duration of therapy: 8-10 wk.
Pneumocystis carinii pneumonia in patient w/ AIDS 600-900 mg IV every 6 hr or 900 mg IV every 8 hr or 300-450 mg PO every 6 hr for 21 days + primaquine 15-30 mg PO once daily for 21 days.
Severe malaria Adult 10 mg/kg quinidine gluconate IV as loading dose over 1-2 hr, then 0.02 mg/kg/min continuous infusion for at least 24 hr. Once parasite density <1% & patient can take oral medication, complete treatment w/ oral quinine + clindamycin 20 mg/kg daily divided tid for 7 days. If patient cannot take oral medication, give 10 mg/kg IV clindamycin loading dose followed by 5 mg/kg IV every 8 hr. Switch to oral clindamycin as soon as patient can take oral medication. Treatment course: 7 days.
Childn Same quinidine gluconate adult dose + oral clindamycin 20 mg/kg daily divided tid for 7 days. If patient cannot take oral medication, give 10 mg/kg clindamycin loading dose IV followed by 5 mg/kg IV every 8 hr. Switch to oral clindamycin as soon as patient can take oral medication. Treatment course: 7 days.
Cap Adult 600-1,800 mg daily divided in 2, 3, or 4 equal doses.
Childn >1 mth who are able to swallow cap 8-25 mg/kg daily in 3 or 4 equal doses.
Mild/moderate diabetic foot infections 300 mg tid-qid for 7-14 days.
Chlamydia trachomatis cervicitis 450-600 mg qid for 10-14 days.
Acute streptococcal tonsilitis/pharyngitis 300 mg bid for 10 days.
Uncomplicated malaria/Plasmodium falciparum Quinine sulfate 650 mg (in adult) or 10 mg/kg (in childn) tid for 3-7 days + clindamycin 20 mg/kg daily divided tid for 7 days.
Prophylaxis of endocarditis in patients sensitive to penicillin 600 mg (in adult) or 20 mg/kg (in childn) 1 hr before procedure. Alternatively, 600 mg IV 1 hr before procedure when parenteral administration is required.
Inj Administer IM as undiluted. Administer IV as diluted then infuse over at least 10-60 min.
Adult Intra-abdominal, female pelvis, other complicated & serious infections 2,400-2,700 mg IM/IV given in 2, 3, or 4 equal doses.
Less complicated infections due to more susceptible microorganisms 1,200-1,800 mg IM/IV daily given in 2, 3, or 4 equal doses. Max daily dose: 4,800 mg.
Childn >1 mth 20-40 mg/kg daily in 3 or 4 equal doses.
Neonates (<1 mth) 15-20 mg/kg daily in 3 or 4 equal doses.
Pelvic inflammatory disease 900 mg IV every 8 hr + IV antibiotic w/ appropriate gm -ve aerobic spectrum. Continue IV for at least 4 days & at least 48 hr after improvement, then continue w/ clindamycin 450-600 mg PO every 6 hr to complete 10-14 days total therapy.
Prophylaxis of infection in head & neck surgery 900 mg diluted in 1,000 mL normal saline as intraoperative irrigant in contaminated head & neck surgery prior to wound closure.
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